assessing the bioadhesivity of acconon mc 8-2 ep/nf for gastroretention of floating microsponges of loratadine and achieving controlled drug delivery

نویسندگان

sonam singh department of pharmaceutics, rajiv academy for pharmacy, mathura, 281001, india

kamla pathak department of pharmaceutics, pharmacy college saifai, uttar pradesh university of medical sciences, saifai, etawah, 206130, india

چکیده

the aim of the present work was to assess the feasibility of accononmc8-2ep/nf as a bioadhesive material for developing controlled release gastroretentive microsponges of loratadine. modified emulsion-solvent diffusion method was employed for the preparation of microsponges (f1-f9) based on 32 factorial design. the amount of ethyl cellulose (ec) and polyvinyl alcohol (pva) were selected as independent variables while particle size, entrapment efficiency and %cdr were designated as dependent variables. the formulation (f1) with least particle size of 54 ± 2.37µm, entrapment efficiency of 65.98 ± 2.21 % and cdr of 88.15 ± 1.59% at 8 h that followed zero order release kinetics was selected as optimized formulation. f1 was re-fabricated as bioadhesive microsponges (bf1) using acconon mc 8-2 and assessed. the particle size of bf1increased to 84 ± 2.29 µm whereas the entrapment efficiency lowered to 55.19 ± 1.36% in comparison to f1. however, the cdr8h from bf1 (81.65 ± 3.37%) was comparable to f1. dynamic in vitro bioadhesion test confirmed the bioadhesive property of bf1. ex vivo permeation across gastric mucin depicted 52.87% cdp8h that followed zero order kinetics (r2 = 0.9885). scanning electron microscopy revealed spherical and highly porous surface. the ftir studies revealed no chemical interaction between drug and excipients. hence, the study affirmed the bioadhesive characteristics of acconon mc 8-2 ep/nf for development of controlled release biaodhesive floating microsponges of loratadine.

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منابع مشابه

Assessing the bioadhesivity of Acconon MC 8-2 EP/NF for gastroretention of floating microsponges of loratadine and achieving controlled drug delivery

The aim of the present work was to assess the feasibility of Acconon MC8-2 EP/NF as a bioadhesive material for developing controlled release gastroretentive microsponges of loratadine. Modified emulsion-solvent diffusion method was employed for the preparation of microsponges (F1-F9) based on  32 factorial design. The amount of ethyl cellulose (EC) and polyvinyl alcohol (PVA) were selected...

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عنوان ژورنال:
pharmaceutical and biomedical research

جلد ۲، شماره ۲، صفحات ۵۸-۷۴

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